Depakine Induced Pseudo-Pelger-Huet Anomaly
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Pseudo-Pelger-Huët anomaly induced by medications: a clinicopathologic study in comparison with myelodysplastic syndrome-related pseudo-Pelger-Huët anomaly.
Pseudo-Pelger-Huët anomaly (PPHA) has been documented in association with transplant medications and other drugs. This iatrogenic neutrophilic dysplasia is reversible with cessation or adjustment of medications but is frequently confused with myelodysplastic syndrome (MDS) based on the conventional concept that PPHA is a marker for dysplasia. We investigated the clinicopathologic features in ia...
متن کاملHomozygous Pelger-Huet anomaly in three different crossbred rabbits: a case report
In this case report, three different crossbreedings of pet rabbits were performed producing affected as well as healthy bunnies. All affected rabbits were smaller and had local alopecia, exophthalmus, and limb deviations compared to their healthy littermates; thus, a homozygous form of Pelger-Huet anomaly was suspected. This anomaly was confirmed by blood examination in which granulocytes with ...
متن کاملCase of acquired or pseudo-Pelger-Huët anomaly
Pelger-Huët anomaly (PHA) is a rare benign autosomal-dominant anomaly with an incidence of ∼1 in 6000. It does not cause neutrophilia, but it can cause a false increase in band forms. It should be differentiated from acquired or pseudo-Pelger-Huët anomaly (PPHA), which has similar morphology, however; it is associated with different pathological states like Myelodysplastic syndrome, as well as ...
متن کاملFunctional and metabolic studies of polymorphonuclear leukocytes in the congenital Pelger-Huet anomaly.
Polymorphonuclear leukocytes (PMNL) from two individuals with congenital Pelger-Huet anomaly (PHA) were examined to determine whether functional or metabolic defects accompanied the known morphological abnormality. No abnormalities of the PHA cells, as compared to normal control cells, were found when tested for quantitative leukocyte enzyme activities, nitroblue tetrazolium reduction, hexose m...
متن کاملSevere generalized muscular atrophia, nerve optic atrophia, ear problem and disability with Pelger-Huet anomaly.
BACKGROUND The Pelger-Huet anomaly dominantly is a rare and benign inherited defect of terminal neutrophil differentiation. Although neutrophil migration may be minimally impaired, granulocytes function is otherwise normal association abnormalities such as ocular, musculoskeletal are reported very rare. Case Presentation : An eight year-old boy with good consciousness but severe muscular atroph...
متن کاملFirst Report on Pelger-Huet Anomaly in a Male Basenji Dog in Libya
Pelger-Huet (P-H) anomaly is a benign congenital anomaly of leukocytes, characterized by nuclear hyposegmentation of granulocytes. Patients with heterozygous form of P-H anomaly are not immunodeficient and not predisposed to infection. In this study, P-H anomaly has been detected during a routine blood examination conducted on a clinically normal five years old male Basenji dog. Nuclear hyposeg...
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عنوان ژورنال
دوره 9 شماره None
صفحات 132- 133
تاریخ انتشار 2017-12
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